Huyghe Brewery is a brewery founded in 1906 in Belgium by Leon Huyghe in city of Melle in East Flanders. The site of the brewery has been in operation since 1654. However, the brewery has been modernized and expanded on several occasions since the founding of Huyghe. The brewery's most well known beer is Delirium Tremens, a blonde, Belgian-style trippel.

Huyghe has acquired several smaller Belgian breweries, including Brouwerij Biertoren in 1993, rouwerij Dam (nl) in 1994, and Brouwerij Villers in 1999.